ASSESSING THE POTENTIAL OF UNTARGETED SWATH MASS SPECTROMETRY-BASED METABOLOMICS TO DIFFERENTIATE CLOSELY RELATED EXPOSURES IN OBSERVATIONAL STUDIES

Assessing the Potential of Untargeted SWATH Mass Spectrometry-Based Metabolomics to Differentiate Closely Related Exposures in Observational Studies

Mass spectrometry (MS) is increasingly used in clinical studies to obtain molecular evidence of chemical exposures, such as tobacco smoke, alcohol, and drugs.This evidence can help verify clinical data retrieved through anamnesis or questionnaires and may provide insights into unreported exposures, for example those classified as the same despite s

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The Anatomical Basis for Dystonia: The Motor Network Model

Background: The dystonias include a clinically and etiologically very diverse group of disorders.There are both degenerative and non-degenerative subtypes resulting from genetic or acquired causes.Traditionally, all dystonias have been viewed as disorders of the basal ganglia.However, there has been increasing appreciation for involvement of o

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